The Gene Ontology (GO) is a structured vocabulary of biological functions. The ontology is divided into three domains: biological processes, cellular components, and molecular functions. In total, the ontology contains over 40,000 terms. GO annotations link a gene to a specific GO term to indicate when a gene is associated with a specific biological function.
GO annotations are frequently incorporated into bioinformatics analyses; however, parsing the ontology and annotations can be difficult. This website aims to simplify the process of retreiving GO annotations. The annotations are current (see last updated date) and customizable to an individual user’s needs. Annotations are provided separately for each species.
IDA). While computational annotations generally have good accuracy, they can introduce biases when used to train other computational approaches.
part_ofrelationships. For most use cases, propagated (inferred) annotations are desired.
|) delimited. Below is an example of the formatting:
|GO:0000053||argininosuccinate metabolic process||biological_process||9606||inferred||1||445||ASS1|
|GO:0000054||ribosomal subunit export from nucleus||biological_process||9606||inferred||4||5901|6209|7514|51068||RAN|RPS15|XPO1|NMD3|
|GO:0000055||ribosomal large subunit export from nucleus||biological_process||9606||inferred||3||5901|7514|51068||RAN|XPO1|NMD3|
This resource is published under a CC-BY license. Please cite:
The project was created as part of Project Rephetio:
And benefitted from the contribution of several community participants:
This resource relies on the following projects:
Gene Ontology: tool for the unification of biology
Michael Ashburner, Catherine A. Ball, Judith A. Blake, David Botstein, Heather Butler, J. Michael Cherry, Allan P. Davis, Kara Dolinski, Selina S. Dwight, Janan T. Eppig, … Gavin Sherlock
Nature Genetics (2000-05) https://doi.org/b9gp96
DOI: 10.1038/75556 · PMID: 10802651 · PMCID: PMC3037419
Entrez Gene: gene-centered information at NCBI
Donna Maglott Jim Ostell Kim D. Pruitt Tatiana Tatusova
Nucleic Acids Research (2004-12-17) https://doi.org/dm9v88
DOI: 10.1093/nar/gki031 · PMID: 15608257 · PMCID: PMC539985